Tuesday, April 11, 2017

Eat When You're Hungry, Sleep When You're Tired



Yes, Your Sleep Schedule Is Making You Sick






Icinori


Jet lag makes everyone miserable. But it makes some people mentally ill.


There’s a psychiatric hospital not far from Heathrow Airport that is known for treating bipolar and schizophrenic travelers, some of whom are occasionally found wandering aimlessly through the terminals. A study from the 1980s of 186 of those patients found that those who’d traveled from the west had a higher incidence of mania, while those who’d traveled from the east had a higher incidence of depression.


I saw the same thing in one of my patients who suffered from manic depression. When he got depressed after a vacation to Europe, we assumed he was just disappointed about returning to work. But then he had a fun trip out West and returned home in what’s called a hypomanic state: He was expansive, a fount of creative ideas.


It was clear that his changes in mood weren’t caused by the vacation blues, but by something else. The problem turned out to be a disruption in his circadian rhythm. He didn’t need drugs; he needed the right doses of sleep and sunlight at the right time.


It turns out that that prescription could treat much of what ails us.


Clinicians have long known that there is a strong link between sleep, sunlight and mood. Problems sleeping are often a warning sign or a cause of impending depression, and can make people with bipolar disorder manic. Some 15 years ago, Dr. Francesco Benedetti, a psychiatrist in Milan, and colleagues noticed that hospitalized bipolar patients who were assigned to rooms with views of the east were discharged earlier than those with rooms facing the west — presumably because the early morning light had an antidepressant effect.


The notion that we can manipulate sleep to treat mental illness has also been around for many years. Back in the late 1960s, a German psychiatrist heard about a woman in Tübingen who was hospitalized for depression and claimed that she normally kept her symptoms in check by taking all-night bike rides.

He subsequently demonstrated in a group of depressed patients that a night of complete sleep deprivation produced an immediate, significant improvement in mood in about 60 percent of the group.


Of course, total sleep deprivation is impractical, to say nothing of the fact that you will crash back into depression as soon as you catch back up on sleep. It also just seems counterintuitive that taking sleep away can help someone feel better. After all, most of us think of sleep as comforting and desirable. So how does this work?


One theory is that depressed people have something wrong with their circadian rhythm. Their bodies tend to release melatonin — a hormone that regulates sleep — earlier in the evening than non-depressed people, and they tend to wake up earlier in the morning.


But even if you don’t have depression, your circadian rhythm may cause trouble. Most people’s natural cycle is somewhat longer than the 24-hour solar day, which means that, left to our own devices, we would quickly get out of sync with the external world. That is exactly what happens when humans are isolated from external cues — say, in a lab setting or stuck in a mine.


The reason we don’t all walk around in a state of perpetual jet lag, waking and sleeping at random, is that our circadian rhythm evolved to be tied to the solar day. In other words, our internal clock is easily influenced and kept in check by the daylight cycle.


Most of us have an indirect sense of our internal clock time just by knowing when we prefer to go to bed. But you can get a more objective measure of your circadian rhythm — or chronotype — and advice on what to do about it by taking this simple quiz.


Those with more serious problems than jet lag and late nights may need to make more serious changes.

Researchers have developed a limited form of sleep deprivation that is euphemistically called wake therapy. It has been shown to have sustained antidepressant benefit in patients with bipolar disorder and major depression. The idea is to get up for the day halfway through the usual sleep period, which shifts the circadian clock to an earlier time. It’s thought that this works by realigning the sleep cycle with other circadian rhythms, like changes in levels of body temperature and the stress hormone cortisol, that are also out of sync with each other in depression.


Studies show that it is possible to make wake therapy even more powerful by incorporating two additional interventions: early morning light therapy and what’s called sleep phase advance, in which the patient goes to bed about five to six hours earlier than usual and sleeps for about seven hours. This combination of treatments is called triple chronotherapy, and the typical course involves one night of complete sleep deprivation followed by three nights of phase-advanced sleep and early morning light.


In one study of 60 hospitalized patients with bipolar depression who were taking antidepressants or lithium, 70 percent of those who did not have a history of drug resistance improved rapidly with sleep deprivation and early morning light, and 57 percent remained well after nine months. Encouragingly, 44 percent of patients who had failed to respond to at least one trial of anti-depressants also improved.


In another study, investigators combined chronotherapy with psychotropic medication and found that depressed patients got better within 48 hours — much faster than antidepressants, which typically take four to six weeks to work. A second study of 75 depressed patients who were taking an antidepressant randomly assigned half to also receive chronotherapy and the other half to daily physical exercise. It found that 62 percent of patients remained well at the end of 29 weeks in the chronotherapy group compared with only 38 percent assigned to exercise.


With the possible exception of ketamine, a drug under investigation for treating depression, this therapy is the most rapid antidepressant treatment that we have. About 60 percent of depressed patients feel markedly better within hours. And — with the exception of some fatigue — there are no side effects.

No doubt you are wondering why more depressed patients don’t receive chronotherapy. First, you cannot patent sleep deprivation or light, so there is little financial incentive to invest in this treatment or research.


That seems shortsighted to me. Research into altering the circadian clock to produce powerful antidepressant benefits could lead to the development of drugs that might mimic the effect of sleep deprivation, but without its obvious drawbacks.


Beyond that, doctors don’t learn much about chronobiology in medical school or residency. There are only a handful of doctors and medical centers that administer these treatments. But there is nothing to stop clinicians from incorporating chronotherapy into their practices right now. I already use light and melatonin to help my patients with jet lag and to readjust their circadian rhythm, but it won’t be long before I try triple chronotherapy for my depressed patients who don’t get better with antidepressants.


Whether chronotherapy will prove as widely effective as conventional antidepressants for serious depression is still unknown. But there is no question that we can relieve everyday problems like jet lag and insomnia simply by better aligning our circadian rhythms with the world around us. What could be more natural than that?



Richard A. Friedman is a professor of clinical psychiatry and the director of the psychopharmacology clinic at the Weill Cornell Medical College, and a contributing opinion writer.

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